Naringenin chalcone (b)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

柚皮素查耳酮是从 Machaerium isadelphum（豆科）的茎中天然分离的产物。

Naringenin chalcone is a product natural isolated from stems of Machaerium isadelphum (Fabaceae).

(E)-Naringenin chalcone (25-125 μg/mL, 10 min) inhibits histamine release from rat peritoneal mast cells, with an IC50 value of 68 μg/mL.(E)-Naringenin chalcone (25-50 μM, 8 days) improves adipocyte (3T3-L1) functions by enhancing adiponectin production.(E)-Naringenin chalcone (25-100 μM, 24 h) stimulates the activity of PPARγ in NIH-3T3 cells.(E)-Naringenin chalcone (0-200 μM 24 h) inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated RAW 264 macrophages. RT-PCR Cell Line:3T3-L1 adipocytes Concentration:25-100 μM Incubation Time:8 days Result:Increased adiponectin mRNA levels up to 8.0-fold in a dose-dependent manner. Western Blot Analysis Cell Line:RAW 264 macrophages Concentration:0,25, 50, 100, 200 μM Incubation Time:24 h Result:Suppressed the degradation of IκB-α.

(E)-Naringenin chalcone (0.8 mg/kg, oral administration) shows anti-allergic effect in type I allergic mice.(E)-Naringenin chalcone (0.8 mg/kg, oral administration) suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice. Animal Model:Mouse type I allergic modelDosage:0.8 mg/kg Administration:Oral administration Result:Inhibited the ear-swelling response, with the inhibitory ratio of 46.7%.Animal Model:Allergic airway inflammation induced in miceDosage:0.8 mg/kg Administration:Oral administration, dailyResult:Decreased cell numbers of the infiltrating leukocyte and eosinophils.

2',4,4',6'-TETRAHYDROXYCHALCONE | Chalconaringenin | Isosalipurpol | Chalcononaringenin

Others

Other Targets

5-HT7

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25515-46-2

272.25

C15H12O5

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years